Formation of Antiviral Cytoplasmic Granules during Orthopoxvirus Infection
نویسندگان
چکیده
منابع مشابه
Formation of antiviral cytoplasmic granules during orthopoxvirus infection.
Vaccinia virus (VV) mutants lacking the double-stranded RNA (dsRNA)-binding E3L protein (ΔE3L mutant VV) show restricted replication in most cell types, as dsRNA produced by VV activates protein kinase R (PKR), leading to eIF2α phosphorylation and impaired translation initiation. Here we show that cells infected with ΔE3L mutant VV assemble cytoplasmic granular structures which surround the VV ...
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New class of orthopoxvirus antiviral drugs that block viral maturation.
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Background. Human infection by orthopoxviruses is being reported with increasing frequency, attributed in part to the cessation of smallpox vaccination and concomitant waning of population-level immunity. In July 2015, a female resident of interior Alaska presented to an urgent care clinic with a dermal lesion consistent with poxvirus infection. Laboratory testing of a virus isolated from the l...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2010
ISSN: 0022-538X
DOI: 10.1128/jvi.02247-10